Betadex Sulfobutyl Ether Sodium
Betadex Sulfobutyl Ether Sodium 182410-00-0
Betadex sulfobutyl ether sodium
CAS No.:182410-00-0 Injection grade
Sulfobutyl ether beta cyclodextrin sodium is a high water-soluble anionic cyclodextrin derivative. It can easily form non-covalent inclusion complexes with drug molecules, thus it has the good performances in enhancing drug stability, solubility and safety, reducing drug toxicity and hemolysis, covering up bad smell, and controlling drug release rate.
Sulfobutyl ether beta cyclodextrin sodium
C42H70-nO35 (C4H8O3S Na)n
White to off-white,amorphous powder.
Freely soluble in water,sparingly soluble in methanol,practically insoluble in ethanol, in n-hexane, in 1-butanol, in acetonitrile,in 2-propanol and in ethyl acetate.
Same absorption bands as USP betadex sulfobutyl ether sodium RS.
The retention time of the major peak of sample solution corresponds to the standard solution.
Identification (Average Degree of Substitution)
Identify test are positive for Sodium
Bis(4-sulfobtyl) Ether Disodium
The total aerobic microbial count
The total combined moulds and yeasts count
Clarity of Solution
30%(w/v) solution is clear and essentially free from particles of foreign matter.
Average Degree of Substitution
(% peak area)
Packaging and storage
Preserve in well-closed containers,and store at room temperature. Protect from moisture.
Conclusion: Compliant to the USP42-NF37.
Application of SBECD
Sulfobutyl ether beta cyclodextrin sodium is a new type of anionic high soluble cyclodextrin derivatives, which can be used as a solubilizer, wetting agent, chelating agent (complexing agent) and polyvatent masking agent.
It has been used in injection, oral, nasal and eye medicines. It has a special affinity and inclusion for nitrogen drugs.
Increase the drug's stability ,solubility ,safety (Include drug molecules to form non-covalent) .Reduce renal toxicity, ease drug hemolysis.Control the drug release rate, cover the bad smell.
Packaging & Delivery
Packaging Details: 10kg/drum,20kg/drum
Contact: cyclodextrin,Zhiyuan Biotechnology
Add: Boxing Economic Development Zone, Binzhou, Shandong, China