Sulfobutyl Beta Cyclodextrin Sodium Is Safer To Apply
As a new type of medicinal excipient, sulfobutyl ether beta cyclodextrin sodium has unparalleled advantages of other cyclodextrin derivatives. sulfobutyl ether beta cyclodextrin sodium is non-associated in the body, and is rapidly excreted in the urine in its original form, close to the glomerular filtration rate, mainly distributed in extracellular fluid, and has low binding to plasma proteins.
In the hemolysis test, it was found that the sulfobutyl ether beta cyclodextrin sodium had a hemolytic effect much less than that of beta cyclodextrin, and was obviously dependent on the degree of substitution. As the degree of substitution increased, the hemolysis effect decreased. And sulbubeta-cyclodextrin-sodium nephrotoxicity low serum urinary nitrogen was found in the sulfo-beta-cyclodextrin-sodium group and the physiological sodium chloride solution group were not statistically different.
Pathological examination showed no renal damage with sulfobutyl beta cyclodextrin sodium. Urinary excretion studies have found that sulfobutyl beta cyclodextrin sodium is much faster than beta cyclodextrin, which may be due to the highly polar sulfonic acid group in the molecular structure of sulfobutyl beta cyclodextrin sodium, which leads to heavy Absorption is reduced and urine excretion is reduced.
Sulfobeta-cyclodextrin sodium has no toxic effect on rabbit conjunctiva and cornea, and has less irritation to nasal mucosa than hydroxypropyl-grade cyclodextrin. Animal acute and subacute experiments show that oral sulfobeta-cyclodextrin sodium Safe for the human body, intramuscular injections have no or only slight irritation. So researching the hemolysis and nephrotoxicity of the drugs encapsulated with it will provide corresponding theoretical basis for selecting safer and reliable drug excipients in the future.
The experiment of inclusion of ciprofloxacin, phenytoin, trimethoprim, and sulfazone with sulfobutyl beta cyclodextrin sodium with different degrees of substitution confirmed that the inclusion compound can be used with intravenous injection. It is safer to determine the hemolytic difference of the inclusion complex, and it is safer to determine the renal toxicity. Is a reliable pharmaceutical excipient.
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